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Triple aryne–tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles
One of the most challenging goals of modern synthetic chemistry is to develop multi-step reactions for rapid and efficient access to complex molecules. We report a triple aryne–tetrazine reaction that enables rapid access to a new class of polyaromatic heterocycles. This new reaction, which couples...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570739/ https://www.ncbi.nlm.nih.gov/pubmed/26388984 http://dx.doi.org/10.1039/c5sc01726b |
| Sumario: | One of the most challenging goals of modern synthetic chemistry is to develop multi-step reactions for rapid and efficient access to complex molecules. We report a triple aryne–tetrazine reaction that enables rapid access to a new class of polyaromatic heterocycles. This new reaction, which couples diverse reactivity modes between simple aryne and tetrazine starting materials, proceeds in a single operation and takes less than 5 minutes in air with no metal catalyst. |
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