A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition

BACKGROUND: It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome. CASE PRESENTATION: A 75-year-old Japanese woman presented with nephrotic syndrome, microhematuria and renal insuffi...

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Autores principales: Narita, Ikuyo, Shimada, Michiko, Fujita, Takeshi, Murakami, Reiichi, Nakamura, Masayuki, Nakamura, Norio, Yamabe, Hideaki, Okumura, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570744/
https://www.ncbi.nlm.nih.gov/pubmed/26370133
http://dx.doi.org/10.1186/s12882-015-0147-9
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author Narita, Ikuyo
Shimada, Michiko
Fujita, Takeshi
Murakami, Reiichi
Nakamura, Masayuki
Nakamura, Norio
Yamabe, Hideaki
Okumura, Ken
author_facet Narita, Ikuyo
Shimada, Michiko
Fujita, Takeshi
Murakami, Reiichi
Nakamura, Masayuki
Nakamura, Norio
Yamabe, Hideaki
Okumura, Ken
author_sort Narita, Ikuyo
collection PubMed
description BACKGROUND: It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome. CASE PRESENTATION: A 75-year-old Japanese woman presented with nephrotic syndrome, microhematuria and renal insufficiency. Renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) with IgM and weak C3 deposition. Congo red stain was negative. Electron microscopy demonstrated massive fibrils in the subendothelium, mesangium and subepithelium. The fibrils were partially parallel, partially curved and 17 nm in diameter. Cryoglobulin, hepatitis B virus (HBV) antigen, hepatitis C virus (HCV) antibody or antinuclear antibody were negative. CONCLUSION: We report a case of MPGN associated with peculiar non-amyloid fibril deposition corresponding to neither FGN nor ITG.
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spelling pubmed-45707442015-09-16 A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition Narita, Ikuyo Shimada, Michiko Fujita, Takeshi Murakami, Reiichi Nakamura, Masayuki Nakamura, Norio Yamabe, Hideaki Okumura, Ken BMC Nephrol Case Report BACKGROUND: It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome. CASE PRESENTATION: A 75-year-old Japanese woman presented with nephrotic syndrome, microhematuria and renal insufficiency. Renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) with IgM and weak C3 deposition. Congo red stain was negative. Electron microscopy demonstrated massive fibrils in the subendothelium, mesangium and subepithelium. The fibrils were partially parallel, partially curved and 17 nm in diameter. Cryoglobulin, hepatitis B virus (HBV) antigen, hepatitis C virus (HCV) antibody or antinuclear antibody were negative. CONCLUSION: We report a case of MPGN associated with peculiar non-amyloid fibril deposition corresponding to neither FGN nor ITG. BioMed Central 2015-09-15 /pmc/articles/PMC4570744/ /pubmed/26370133 http://dx.doi.org/10.1186/s12882-015-0147-9 Text en © Narita et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Narita, Ikuyo
Shimada, Michiko
Fujita, Takeshi
Murakami, Reiichi
Nakamura, Masayuki
Nakamura, Norio
Yamabe, Hideaki
Okumura, Ken
A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title_full A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title_fullStr A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title_full_unstemmed A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title_short A case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
title_sort case of membranoproliferative glomerulonephritis associated withcurved fibril deposition
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570744/
https://www.ncbi.nlm.nih.gov/pubmed/26370133
http://dx.doi.org/10.1186/s12882-015-0147-9
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