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Natural Th17 cells are critically regulated by functional medullary thymic microenvironments

The thymic medulla is critical for the enforcement of central tolerance. In addition to deletion of auto-reactive T-cells, the thymic medulla supports the maturation of heterogeneous natural αβT-cells linked to tolerance mechanisms. Natural IL-17-secreting CD4(+)αβT-cells (nTh17) represent recently...

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Detalles Bibliográficos
Autores principales:	Jenkinson, William E., McCarthy, Nicholas I., Dutton, Emma E., Cowan, Jennifer E., Parnell, Sonia M., White, Andrea J., Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570931/ https://www.ncbi.nlm.nih.gov/pubmed/26143957 http://dx.doi.org/10.1016/j.jaut.2015.06.008

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