Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum

The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, t...

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Detalles Bibliográficos
Autores principales: Haldipur, Parthiv, Sivaprakasam, Iswariya, Periasamy, Vinod, Govindan, Subashika, Mani, Shyamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571082/
https://www.ncbi.nlm.nih.gov/pubmed/25979710
http://dx.doi.org/10.1242/bio.009886
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author Haldipur, Parthiv
Sivaprakasam, Iswariya
Periasamy, Vinod
Govindan, Subashika
Mani, Shyamala
author_facet Haldipur, Parthiv
Sivaprakasam, Iswariya
Periasamy, Vinod
Govindan, Subashika
Mani, Shyamala
author_sort Haldipur, Parthiv
collection PubMed
description The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.
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spelling pubmed-45710822015-09-17 Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum Haldipur, Parthiv Sivaprakasam, Iswariya Periasamy, Vinod Govindan, Subashika Mani, Shyamala Biol Open Research Article The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue. The Company of Biologists 2015-05-15 /pmc/articles/PMC4571082/ /pubmed/25979710 http://dx.doi.org/10.1242/bio.009886 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Haldipur, Parthiv
Sivaprakasam, Iswariya
Periasamy, Vinod
Govindan, Subashika
Mani, Shyamala
Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title_full Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title_fullStr Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title_full_unstemmed Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title_short Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
title_sort asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571082/
https://www.ncbi.nlm.nih.gov/pubmed/25979710
http://dx.doi.org/10.1242/bio.009886
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