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Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation

BACKGROUND: Genome wide-association studies have successfully identified several hundred independent loci harboring common cancer susceptibility alleles that are distinct from the more than 110 cancer predisposition genes. The latter are generally characterized by disruptive mutations in coding gene...

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Detalles Bibliográficos
Autores principales:	Machiela, Mitchell J., Ho, Brian M., Fisher, Victoria A., Hua, Xing, Chanock, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571124/ https://www.ncbi.nlm.nih.gov/pubmed/26374197 http://dx.doi.org/10.1186/s13059-015-0755-5

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