A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?

[Image: see text] Uncontrolled inflammation or oxidative stress generates electron-deficient species that oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences regulating the c-MYC, KRAS, VEGF, BCL-2, HIF-1α, and RET oncogenes, as examples, are targets for oxidatio...

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Detalles Bibliográficos
Autores principales: Fleming, Aaron M., Zhou, Jia, Wallace, Susan S., Burrows, Cynthia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571166/
https://www.ncbi.nlm.nih.gov/pubmed/26405692
http://dx.doi.org/10.1021/acscentsci.5b00202

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