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The role of the orphan nuclear receptor COUP-TFII in tumorigenesis
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571324/ https://www.ncbi.nlm.nih.gov/pubmed/25283503 http://dx.doi.org/10.1038/aps.2014.86 |
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author | Xu, Mafei Qin, Jun Tsai, Sophia Y Tsai, Ming-jer |
author_facet | Xu, Mafei Qin, Jun Tsai, Sophia Y Tsai, Ming-jer |
author_sort | Xu, Mafei |
collection | PubMed |
description | The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms. |
format | Online Article Text |
id | pubmed-4571324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45713242015-09-28 The role of the orphan nuclear receptor COUP-TFII in tumorigenesis Xu, Mafei Qin, Jun Tsai, Sophia Y Tsai, Ming-jer Acta Pharmacol Sin Review The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms. Nature Publishing Group 2015-01 2014-10-06 /pmc/articles/PMC4571324/ /pubmed/25283503 http://dx.doi.org/10.1038/aps.2014.86 Text en Copyright © 2015 CPS and SIMM http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Xu, Mafei Qin, Jun Tsai, Sophia Y Tsai, Ming-jer The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title_full | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title_fullStr | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title_full_unstemmed | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title_short | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis |
title_sort | role of the orphan nuclear receptor coup-tfii in tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571324/ https://www.ncbi.nlm.nih.gov/pubmed/25283503 http://dx.doi.org/10.1038/aps.2014.86 |
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