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Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one

In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The di­fluoro­phenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond,...

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Detalles Bibliográficos
Autores principales: Fathimunnisa, M., Manikandan, H., Selvanayagam, S., Sridhar, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571355/
https://www.ncbi.nlm.nih.gov/pubmed/26396754
http://dx.doi.org/10.1107/S2056989015012931
Descripción
Sumario:In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The di­fluoro­phenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond, which forms an R (2) (2)(8) motif, and a C—H⋯O inter­action, which generates a C(8) chain along [010]. In addition, this chain structure is stabilized by C—H⋯π inter­actions. In one of the pyrrolidine rings, the methyl­ene group forming the flap of an envelope and the H atoms of the adjacent methyl­ene groups are disordered over two sets of sites, with site-occupancy factors of 0.571 (4) and 0.429 (4)