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Crystal structure of 2′-[(2′,4′-difluorobiphenyl-4-yl)carbonyl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexahydrospiro[indole-3,3′-pyrrolizin]-2(1H)-one
In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The difluorophenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571355/ https://www.ncbi.nlm.nih.gov/pubmed/26396754 http://dx.doi.org/10.1107/S2056989015012931 |
Sumario: | In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The difluorophenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond, which forms an R (2) (2)(8) motif, and a C—H⋯O interaction, which generates a C(8) chain along [010]. In addition, this chain structure is stabilized by C—H⋯π interactions. In one of the pyrrolidine rings, the methylene group forming the flap of an envelope and the H atoms of the adjacent methylene groups are disordered over two sets of sites, with site-occupancy factors of 0.571 (4) and 0.429 (4) |
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