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Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one

In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The di­fluoro­phenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond,...

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Autores principales: Fathimunnisa, M., Manikandan, H., Selvanayagam, S., Sridhar, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571355/
https://www.ncbi.nlm.nih.gov/pubmed/26396754
http://dx.doi.org/10.1107/S2056989015012931
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author Fathimunnisa, M.
Manikandan, H.
Selvanayagam, S.
Sridhar, B.
author_facet Fathimunnisa, M.
Manikandan, H.
Selvanayagam, S.
Sridhar, B.
author_sort Fathimunnisa, M.
collection PubMed
description In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The di­fluoro­phenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond, which forms an R (2) (2)(8) motif, and a C—H⋯O inter­action, which generates a C(8) chain along [010]. In addition, this chain structure is stabilized by C—H⋯π inter­actions. In one of the pyrrolidine rings, the methyl­ene group forming the flap of an envelope and the H atoms of the adjacent methyl­ene groups are disordered over two sets of sites, with site-occupancy factors of 0.571 (4) and 0.429 (4)
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spelling pubmed-45713552015-09-22 Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one Fathimunnisa, M. Manikandan, H. Selvanayagam, S. Sridhar, B. Acta Crystallogr E Crystallogr Commun Research Communications In the title pyrrolizidine derivative, C(33)H(26)F(2)N(2)O(2), both pyrrolidine rings of the pyrrolizidine moiety adopt an envelope conformation. The di­fluoro­phenyl group is oriented at an angle of 54.3 (1)° with respect to the oxindole moiety. The crystal packing features an N—H⋯O hydrogen bond, which forms an R (2) (2)(8) motif, and a C—H⋯O inter­action, which generates a C(8) chain along [010]. In addition, this chain structure is stabilized by C—H⋯π inter­actions. In one of the pyrrolidine rings, the methyl­ene group forming the flap of an envelope and the H atoms of the adjacent methyl­ene groups are disordered over two sets of sites, with site-occupancy factors of 0.571 (4) and 0.429 (4) International Union of Crystallography 2015-07-11 /pmc/articles/PMC4571355/ /pubmed/26396754 http://dx.doi.org/10.1107/S2056989015012931 Text en © Fathimunnisa et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Communications
Fathimunnisa, M.
Manikandan, H.
Selvanayagam, S.
Sridhar, B.
Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title_full Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title_fullStr Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title_full_unstemmed Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title_short Crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1H)-one
title_sort crystal structure of 2′-[(2′,4′-di­fluoro­biphenyl-4-yl)carbon­yl]-1′-phenyl-1′,2′,5′,6′,7′,7a’-hexa­hydro­spiro­[indole-3,3′-pyrrolizin]-2(1h)-one
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571355/
https://www.ncbi.nlm.nih.gov/pubmed/26396754
http://dx.doi.org/10.1107/S2056989015012931
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