Cargando…

New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation

The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from diverse eukaryotic lineages. There is now evidence that this mechanism has co...

Descripción completa

Detalles Bibliográficos
Autores principales: McLysaght, Aoife, Guerzoni, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571571/
https://www.ncbi.nlm.nih.gov/pubmed/26323763
http://dx.doi.org/10.1098/rstb.2014.0332
_version_ 1782390349131415552
author McLysaght, Aoife
Guerzoni, Daniele
author_facet McLysaght, Aoife
Guerzoni, Daniele
author_sort McLysaght, Aoife
collection PubMed
description The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from diverse eukaryotic lineages. There is now evidence that this mechanism has contributed a significant number of genes to genomes of organisms as diverse as Saccharomyces, Drosophila, Plasmodium, Arabidopisis and human. From simple beginnings, these genes have in some instances acquired complex structure, regulated expression and important functional roles. New genes are often thought of as dispensable late additions; however, some recent de novo genes in human can play a role in disease. Rather than an extremely rare occurrence, it is now evident that there is a relatively constant trickle of proto-genes released into the testing ground of natural selection. It is currently unknown whether de novo genes arise primarily through an ‘RNA-first’ or ‘ORF-first’ pathway. Either way, evolutionary tinkering with this pool of genetic potential may have been a significant player in the origins of lineage-specific traits and adaptations.
format Online
Article
Text
id pubmed-4571571
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-45715712015-09-26 New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation McLysaght, Aoife Guerzoni, Daniele Philos Trans R Soc Lond B Biol Sci Articles The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from diverse eukaryotic lineages. There is now evidence that this mechanism has contributed a significant number of genes to genomes of organisms as diverse as Saccharomyces, Drosophila, Plasmodium, Arabidopisis and human. From simple beginnings, these genes have in some instances acquired complex structure, regulated expression and important functional roles. New genes are often thought of as dispensable late additions; however, some recent de novo genes in human can play a role in disease. Rather than an extremely rare occurrence, it is now evident that there is a relatively constant trickle of proto-genes released into the testing ground of natural selection. It is currently unknown whether de novo genes arise primarily through an ‘RNA-first’ or ‘ORF-first’ pathway. Either way, evolutionary tinkering with this pool of genetic potential may have been a significant player in the origins of lineage-specific traits and adaptations. The Royal Society 2015-09-26 /pmc/articles/PMC4571571/ /pubmed/26323763 http://dx.doi.org/10.1098/rstb.2014.0332 Text en © 2015 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
McLysaght, Aoife
Guerzoni, Daniele
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title_full New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title_fullStr New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title_full_unstemmed New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title_short New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
title_sort new genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571571/
https://www.ncbi.nlm.nih.gov/pubmed/26323763
http://dx.doi.org/10.1098/rstb.2014.0332
work_keys_str_mv AT mclysaghtaoife newgenesfromnoncodingsequencetheroleofdenovoproteincodinggenesineukaryoticevolutionaryinnovation
AT guerzonidaniele newgenesfromnoncodingsequencetheroleofdenovoproteincodinggenesineukaryoticevolutionaryinnovation