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Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins

Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitination and subsequent proteasome-dependent degradation of...

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Detalles Bibliográficos
Autores principales:	Ju Shin, Yeong, Kyun Park, Seung, Jung Jung, Yoo, Na Kim, Ye, Sung Kim, Ki, Kyu Park, Ok, Kwon, Seung-Hae, Ho Jeon, Sung, Trinh, Le A., Fraser, Scott E., Kee, Yun, Joon Hwang, Byung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571616/ https://www.ncbi.nlm.nih.gov/pubmed/26373678 http://dx.doi.org/10.1038/srep14269

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