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ALK-rearranged squamous cell carcinoma of the lung
The fusion gene echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) is identified in approximately 5% of non-small-cell lung cancer patients. A rare case of ALK-positive squamous cell carcinoma of the lung is reported. A 60-year-old man, an ex-smoker with a 720-p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571740/ https://www.ncbi.nlm.nih.gov/pubmed/26392858 http://dx.doi.org/10.1002/rcr2.115 |
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author | Takanashi, Yusuke Tajima, Shogo Matsuura, Shun Koyama, Shin Takahashi, Tsuyoshi Neyatani, Hiroshi |
author_facet | Takanashi, Yusuke Tajima, Shogo Matsuura, Shun Koyama, Shin Takahashi, Tsuyoshi Neyatani, Hiroshi |
author_sort | Takanashi, Yusuke |
collection | PubMed |
description | The fusion gene echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) is identified in approximately 5% of non-small-cell lung cancer patients. A rare case of ALK-positive squamous cell carcinoma of the lung is reported. A 60-year-old man, an ex-smoker with a 720-packs-per-year tobacco smoking history, presented with a mass lesion in the upper lobe of the left lung on chest computed tomography. Transbronchial biopsy of the mass confirmed a diagnosis of lung squamous cell carcinoma, and it was proven to have ALK rearrangement by fluorescent in situ hybridization. The patient underwent left upper lobectomy. Hematoxylin and eosin staining of the surgical specimen demonstrated the typical morphology of pure squamous cell carcinoma. The patient has been advised to attend regular check-ups for postoperative recurrence. ALK testing and subsequent ALK-targeted treatment can be a possible option in cases of postoperative recurrence. |
format | Online Article Text |
id | pubmed-4571740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45717402015-09-21 ALK-rearranged squamous cell carcinoma of the lung Takanashi, Yusuke Tajima, Shogo Matsuura, Shun Koyama, Shin Takahashi, Tsuyoshi Neyatani, Hiroshi Respirol Case Rep Case Reports The fusion gene echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) is identified in approximately 5% of non-small-cell lung cancer patients. A rare case of ALK-positive squamous cell carcinoma of the lung is reported. A 60-year-old man, an ex-smoker with a 720-packs-per-year tobacco smoking history, presented with a mass lesion in the upper lobe of the left lung on chest computed tomography. Transbronchial biopsy of the mass confirmed a diagnosis of lung squamous cell carcinoma, and it was proven to have ALK rearrangement by fluorescent in situ hybridization. The patient underwent left upper lobectomy. Hematoxylin and eosin staining of the surgical specimen demonstrated the typical morphology of pure squamous cell carcinoma. The patient has been advised to attend regular check-ups for postoperative recurrence. ALK testing and subsequent ALK-targeted treatment can be a possible option in cases of postoperative recurrence. John Wiley & Sons, Ltd 2015-09 2015-07-02 /pmc/articles/PMC4571740/ /pubmed/26392858 http://dx.doi.org/10.1002/rcr2.115 Text en © 2015 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Takanashi, Yusuke Tajima, Shogo Matsuura, Shun Koyama, Shin Takahashi, Tsuyoshi Neyatani, Hiroshi ALK-rearranged squamous cell carcinoma of the lung |
title | ALK-rearranged squamous cell carcinoma of the lung |
title_full | ALK-rearranged squamous cell carcinoma of the lung |
title_fullStr | ALK-rearranged squamous cell carcinoma of the lung |
title_full_unstemmed | ALK-rearranged squamous cell carcinoma of the lung |
title_short | ALK-rearranged squamous cell carcinoma of the lung |
title_sort | alk-rearranged squamous cell carcinoma of the lung |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571740/ https://www.ncbi.nlm.nih.gov/pubmed/26392858 http://dx.doi.org/10.1002/rcr2.115 |
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