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Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571826/ https://www.ncbi.nlm.nih.gov/pubmed/26360822 http://dx.doi.org/10.12659/AJCR.894274 |
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author | Okada, Atsushi Iida, Keitaro Hamakawa, Takashi Umemoto, Yukihiro Yasui, Takahiro Kawai, Noriyasu Tozawa, Keiichi Sasaki, Shoichi Hayashi, Yutaro Kohri, Kenjiro |
author_facet | Okada, Atsushi Iida, Keitaro Hamakawa, Takashi Umemoto, Yukihiro Yasui, Takahiro Kawai, Noriyasu Tozawa, Keiichi Sasaki, Shoichi Hayashi, Yutaro Kohri, Kenjiro |
author_sort | Okada, Atsushi |
collection | PubMed |
description | Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. CASE REPORT: We report a case of a metastatic NEC of the kidney and bladder in a 77-year-old woman who underwent renal biopsy and transurethral resection of the bladder tumor. Pathological examination revealed NEC in the kidney and the bladder samples. Immunohistochemical examination revealed strongly positive staining for synaptophysin, chromogranin A, and CD56, and focally positive staining for cytokeratin AE 1/3 and Cam 5.2. Fluorescence in situ hybridization confirmed the increased chromosome 3 copy number, and loss of hybridization in 3q21, 5q22–23, 10q26, and 13q14 was detected when the tumor samples were compared with normal samples. CONCLUSIONS: This is a rare case of NEC-specific genetic abnormalities in a kidney-derived tumor, and is the first report to identify kidney-derived NEC that metastasized to the bladder via the urinary tract. |
format | Online Article Text |
id | pubmed-4571826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45718262015-09-25 Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number Okada, Atsushi Iida, Keitaro Hamakawa, Takashi Umemoto, Yukihiro Yasui, Takahiro Kawai, Noriyasu Tozawa, Keiichi Sasaki, Shoichi Hayashi, Yutaro Kohri, Kenjiro Am J Case Rep Articles Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. CASE REPORT: We report a case of a metastatic NEC of the kidney and bladder in a 77-year-old woman who underwent renal biopsy and transurethral resection of the bladder tumor. Pathological examination revealed NEC in the kidney and the bladder samples. Immunohistochemical examination revealed strongly positive staining for synaptophysin, chromogranin A, and CD56, and focally positive staining for cytokeratin AE 1/3 and Cam 5.2. Fluorescence in situ hybridization confirmed the increased chromosome 3 copy number, and loss of hybridization in 3q21, 5q22–23, 10q26, and 13q14 was detected when the tumor samples were compared with normal samples. CONCLUSIONS: This is a rare case of NEC-specific genetic abnormalities in a kidney-derived tumor, and is the first report to identify kidney-derived NEC that metastasized to the bladder via the urinary tract. International Scientific Literature, Inc. 2015-09-11 /pmc/articles/PMC4571826/ /pubmed/26360822 http://dx.doi.org/10.12659/AJCR.894274 Text en © Am J Case Rep, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Articles Okada, Atsushi Iida, Keitaro Hamakawa, Takashi Umemoto, Yukihiro Yasui, Takahiro Kawai, Noriyasu Tozawa, Keiichi Sasaki, Shoichi Hayashi, Yutaro Kohri, Kenjiro Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title | Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title_full | Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title_fullStr | Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title_full_unstemmed | Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title_short | Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number |
title_sort | neuroendocrine carcinoma of the kidney and bladder with loss of heterozygosity and changes in chromosome 3 copy number |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571826/ https://www.ncbi.nlm.nih.gov/pubmed/26360822 http://dx.doi.org/10.12659/AJCR.894274 |
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