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Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number

Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine...

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Autores principales: Okada, Atsushi, Iida, Keitaro, Hamakawa, Takashi, Umemoto, Yukihiro, Yasui, Takahiro, Kawai, Noriyasu, Tozawa, Keiichi, Sasaki, Shoichi, Hayashi, Yutaro, Kohri, Kenjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571826/
https://www.ncbi.nlm.nih.gov/pubmed/26360822
http://dx.doi.org/10.12659/AJCR.894274
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author Okada, Atsushi
Iida, Keitaro
Hamakawa, Takashi
Umemoto, Yukihiro
Yasui, Takahiro
Kawai, Noriyasu
Tozawa, Keiichi
Sasaki, Shoichi
Hayashi, Yutaro
Kohri, Kenjiro
author_facet Okada, Atsushi
Iida, Keitaro
Hamakawa, Takashi
Umemoto, Yukihiro
Yasui, Takahiro
Kawai, Noriyasu
Tozawa, Keiichi
Sasaki, Shoichi
Hayashi, Yutaro
Kohri, Kenjiro
author_sort Okada, Atsushi
collection PubMed
description Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. CASE REPORT: We report a case of a metastatic NEC of the kidney and bladder in a 77-year-old woman who underwent renal biopsy and transurethral resection of the bladder tumor. Pathological examination revealed NEC in the kidney and the bladder samples. Immunohistochemical examination revealed strongly positive staining for synaptophysin, chromogranin A, and CD56, and focally positive staining for cytokeratin AE 1/3 and Cam 5.2. Fluorescence in situ hybridization confirmed the increased chromosome 3 copy number, and loss of hybridization in 3q21, 5q22–23, 10q26, and 13q14 was detected when the tumor samples were compared with normal samples. CONCLUSIONS: This is a rare case of NEC-specific genetic abnormalities in a kidney-derived tumor, and is the first report to identify kidney-derived NEC that metastasized to the bladder via the urinary tract.
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spelling pubmed-45718262015-09-25 Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number Okada, Atsushi Iida, Keitaro Hamakawa, Takashi Umemoto, Yukihiro Yasui, Takahiro Kawai, Noriyasu Tozawa, Keiichi Sasaki, Shoichi Hayashi, Yutaro Kohri, Kenjiro Am J Case Rep Articles Patient: Female, 77 Final Diagnosis: Neuroendocrine carcinoma of the kidney and bladder Symptoms: Right lumbar pain Medication: None Clinical Procedure: CT • needele biopsy of renal tumor • transyrethral resection of bladder tumor Specialty: Urology OBJECTIVE: Rare disease BACKGROUND: Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. CASE REPORT: We report a case of a metastatic NEC of the kidney and bladder in a 77-year-old woman who underwent renal biopsy and transurethral resection of the bladder tumor. Pathological examination revealed NEC in the kidney and the bladder samples. Immunohistochemical examination revealed strongly positive staining for synaptophysin, chromogranin A, and CD56, and focally positive staining for cytokeratin AE 1/3 and Cam 5.2. Fluorescence in situ hybridization confirmed the increased chromosome 3 copy number, and loss of hybridization in 3q21, 5q22–23, 10q26, and 13q14 was detected when the tumor samples were compared with normal samples. CONCLUSIONS: This is a rare case of NEC-specific genetic abnormalities in a kidney-derived tumor, and is the first report to identify kidney-derived NEC that metastasized to the bladder via the urinary tract. International Scientific Literature, Inc. 2015-09-11 /pmc/articles/PMC4571826/ /pubmed/26360822 http://dx.doi.org/10.12659/AJCR.894274 Text en © Am J Case Rep, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Articles
Okada, Atsushi
Iida, Keitaro
Hamakawa, Takashi
Umemoto, Yukihiro
Yasui, Takahiro
Kawai, Noriyasu
Tozawa, Keiichi
Sasaki, Shoichi
Hayashi, Yutaro
Kohri, Kenjiro
Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title_full Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title_fullStr Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title_full_unstemmed Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title_short Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
title_sort neuroendocrine carcinoma of the kidney and bladder with loss of heterozygosity and changes in chromosome 3 copy number
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571826/
https://www.ncbi.nlm.nih.gov/pubmed/26360822
http://dx.doi.org/10.12659/AJCR.894274
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