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Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease

Antibodies to the autoantigen transglutaminase 2 (TG2) are a hallmark of celiac disease. We have studied the interaction between TG2 and an anti-TG2 antibody (679-14-E06) derived from a single gut IgA plasma cell of a celiac disease patient. The antibody recognizes one of four identified epitopes ta...

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Detalles Bibliográficos
Autores principales:	Chen, Xi, Hnida, Kathrin, Graewert, Melissa Ann, Andersen, Jan Terje, Iversen, Rasmus, Tuukkanen, Anne, Svergun, Dmitri, Sollid, Ludvig M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571865/ https://www.ncbi.nlm.nih.gov/pubmed/26160175 http://dx.doi.org/10.1074/jbc.M115.669895

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