Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells

Pancreatic β cells are electrically excitable and respond to elevated glucose concentrations with bursts of Ca(2+) action potentials due to the activation of voltage-dependent Ca(2+) channels (VDCCs), which leads to the exocytosis of insulin granules. We have examined the possible role of nicotinic...

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Detalles Bibliográficos
Autores principales: Arredouani, Abdelilah, Ruas, Margarida, Collins, Stephan C., Parkesh, Raman, Clough, Frederick, Pillinger, Toby, Coltart, George, Rietdorf, Katja, Royle, Andrew, Johnson, Paul, Braun, Matthias, Zhang, Quan, Sones, William, Shimomura, Kenju, Morgan, Anthony J., Lewis, Alexander M., Chuang, Kai-Ting, Tunn, Ruth, Gadea, Joaquin, Teboul, Lydia, Heister, Paula M., Tynan, Patricia W., Bellomo, Elisa A., Rutter, Guy A., Rorsman, Patrik, Churchill, Grant C., Parrington, John, Galione, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571866/
https://www.ncbi.nlm.nih.gov/pubmed/26152717
http://dx.doi.org/10.1074/jbc.M115.671248

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