Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma

PRDM1/Blimp-1 is a tumor suppressor gene in the activated B-cell subtype of diffuse large B-cell lymphomas. Its inactivation contributes to pathogenesis in this setting by impairing terminal B-cell differentiation induced by constitutive nuclear factor-κB activation. The role of PRDM1 in Burkitt lym...

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Detalles Bibliográficos
Autores principales: Zhang, T, Ma, J, Nie, K, Yan, J, Liu, Y, Bacchi, C E, Queiroga, E M, Gualco, G, Sample, J T, Orazi, A, Knowles, D M, Tam, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571983/
https://www.ncbi.nlm.nih.gov/pubmed/25382611
http://dx.doi.org/10.1038/bcj.2014.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571983/
https://www.ncbi.nlm.nih.gov/pubmed/25382611
http://dx.doi.org/10.1038/bcj.2014.75

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