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A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model

BACKGROUND: Recently, a Korean fracture-risk assessment tool (FRAX) model has become available, but large prospective cohort studies, which are needed to validate the model, are still lacking, and there has been little effort to evaluate its usefulness. This study evaluated the clinical usefulness o...

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Autores principales: Min, Yong-Ki, Lee, Dong-Yun, Park, Youn-Soo, Moon, Young-Wan, Lim, Seung-Jae, Lee, Young-Kyun, Choi, DooSeok, Yoon, Byung-Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572032/
https://www.ncbi.nlm.nih.gov/pubmed/26389086
http://dx.doi.org/10.11005/jbm.2015.22.3.113
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author Min, Yong-Ki
Lee, Dong-Yun
Park, Youn-Soo
Moon, Young-Wan
Lim, Seung-Jae
Lee, Young-Kyun
Choi, DooSeok
Yoon, Byung-Koo
author_facet Min, Yong-Ki
Lee, Dong-Yun
Park, Youn-Soo
Moon, Young-Wan
Lim, Seung-Jae
Lee, Young-Kyun
Choi, DooSeok
Yoon, Byung-Koo
author_sort Min, Yong-Ki
collection PubMed
description BACKGROUND: Recently, a Korean fracture-risk assessment tool (FRAX) model has become available, but large prospective cohort studies, which are needed to validate the model, are still lacking, and there has been little effort to evaluate its usefulness. This study evaluated the clinical usefulness of the FRAX model, a FRAX developed by the World Health Organization, in Korea. METHODS: In 405 postmenopausal women and 139 men with a proximal femoral fracture, 10-year predicted fracture probabilities calculated by the Korean FRAX model (a country-specific model) were compared with the probabilities calculated with a FRAX model for Japan, which has a similar ethnic background (surrogate model). RESULTS: The 10-year probabilities of major osteoporotic and hip fractures calculated by the Korean model were significantly lower than those calculated by the Japanese model in women and men. The fracture probabilities calculated by each model increased significantly with age in both sexes. In patients aged 70 or older, however, there was a significant difference between the two models. In addition, the Korean model led to lower probabilities for major osteoporotic fracture and hip fracture in women when BMD was excluded from the model than when it was included. CONCLUSIONS: The 10-year fracture probabilities calculated with FRAX models might differ between country-specific and surrogate models, and caution is needed when applying a surrogate model to a new population. A large prospective study is warranted to validate the country-specific Korean model in the general population.
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spelling pubmed-45720322015-09-18 A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model Min, Yong-Ki Lee, Dong-Yun Park, Youn-Soo Moon, Young-Wan Lim, Seung-Jae Lee, Young-Kyun Choi, DooSeok Yoon, Byung-Koo J Bone Metab Original Article BACKGROUND: Recently, a Korean fracture-risk assessment tool (FRAX) model has become available, but large prospective cohort studies, which are needed to validate the model, are still lacking, and there has been little effort to evaluate its usefulness. This study evaluated the clinical usefulness of the FRAX model, a FRAX developed by the World Health Organization, in Korea. METHODS: In 405 postmenopausal women and 139 men with a proximal femoral fracture, 10-year predicted fracture probabilities calculated by the Korean FRAX model (a country-specific model) were compared with the probabilities calculated with a FRAX model for Japan, which has a similar ethnic background (surrogate model). RESULTS: The 10-year probabilities of major osteoporotic and hip fractures calculated by the Korean model were significantly lower than those calculated by the Japanese model in women and men. The fracture probabilities calculated by each model increased significantly with age in both sexes. In patients aged 70 or older, however, there was a significant difference between the two models. In addition, the Korean model led to lower probabilities for major osteoporotic fracture and hip fracture in women when BMD was excluded from the model than when it was included. CONCLUSIONS: The 10-year fracture probabilities calculated with FRAX models might differ between country-specific and surrogate models, and caution is needed when applying a surrogate model to a new population. A large prospective study is warranted to validate the country-specific Korean model in the general population. The Korean Society for Bone and Mineral Research 2015-08 2015-08-31 /pmc/articles/PMC4572032/ /pubmed/26389086 http://dx.doi.org/10.11005/jbm.2015.22.3.113 Text en Copyright © 2015 The Korean Society for Bone and Mineral Research http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Min, Yong-Ki
Lee, Dong-Yun
Park, Youn-Soo
Moon, Young-Wan
Lim, Seung-Jae
Lee, Young-Kyun
Choi, DooSeok
Yoon, Byung-Koo
A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title_full A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title_fullStr A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title_full_unstemmed A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title_short A FRAX Experience in Korea: Fracture Risk Probabilities with a Country-specific Versus a Surrogate Model
title_sort frax experience in korea: fracture risk probabilities with a country-specific versus a surrogate model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572032/
https://www.ncbi.nlm.nih.gov/pubmed/26389086
http://dx.doi.org/10.11005/jbm.2015.22.3.113
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