Cargando…

Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe

Anthelmintic resistance has been increasingly reported in cattle worldwide over the last decade, although reports from Europe are more limited. The objective of the present study was to evaluate the efficacy of injectable formulations of ivermectin and moxidectin at 0.2 mg per kg bodyweight against...

Descripción completa

Detalles Bibliográficos
Autores principales: Geurden, Thomas, Chartier, Christophe, Fanke, Jane, di Regalbono, Antonio Frangipane, Traversa, Donato, von Samson-Himmelstjerna, Georg, Demeler, Janina, Vanimisetti, Hima Bindu, Bartram, David J., Denwood, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572401/
https://www.ncbi.nlm.nih.gov/pubmed/26448902
http://dx.doi.org/10.1016/j.ijpddr.2015.08.001
_version_ 1782390393763004416
author Geurden, Thomas
Chartier, Christophe
Fanke, Jane
di Regalbono, Antonio Frangipane
Traversa, Donato
von Samson-Himmelstjerna, Georg
Demeler, Janina
Vanimisetti, Hima Bindu
Bartram, David J.
Denwood, Matthew J.
author_facet Geurden, Thomas
Chartier, Christophe
Fanke, Jane
di Regalbono, Antonio Frangipane
Traversa, Donato
von Samson-Himmelstjerna, Georg
Demeler, Janina
Vanimisetti, Hima Bindu
Bartram, David J.
Denwood, Matthew J.
author_sort Geurden, Thomas
collection PubMed
description Anthelmintic resistance has been increasingly reported in cattle worldwide over the last decade, although reports from Europe are more limited. The objective of the present study was to evaluate the efficacy of injectable formulations of ivermectin and moxidectin at 0.2 mg per kg bodyweight against naturally acquired gastro-intestinal nematodes in cattle. A total of 753 animals on 40 farms were enrolled in Germany (12 farms), the UK (10 farms), Italy (10 farms), and France (8 farms). Animals were selected based on pre-treatment faecal egg counts and were allocated to one of the two treatment groups. Each treatment group consisted of between 7 and 10 animals. A post-treatment faecal egg count was performed 14 days (±2 days) after treatment. The observed percentage reduction was calculated for each treatment group based on the arithmetic mean faecal egg count before and after treatment. The resistance status was evaluated based on the reduction in arithmetic mean faecal egg count and both the lower and upper 95% confidence limits. A decreased efficacy was observed in half or more of the farms in Germany, France and the UK. For moxidectin, resistance was confirmed on 3 farms in France, and on 1 farm in Germany and the UK. For ivermectin, resistance was confirmed on 3 farms in the UK, and on 1 farm in Germany and France. The remaining farms with decreased efficacy were classified as having an inconclusive resistance status based on the available data. After treatment Cooperia spp. larvae were most frequently identified, though Ostertagia ostertagi was also found, in particular within the UK and Germany. The present study reports lower than expected efficacy for ivermectin and moxidectin (based on the reduction in egg excretion after treatment) on European cattle farms, with confirmed anthelmintic resistance on 12.5% of the farms.
format Online
Article
Text
id pubmed-4572401
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-45724012015-10-07 Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe Geurden, Thomas Chartier, Christophe Fanke, Jane di Regalbono, Antonio Frangipane Traversa, Donato von Samson-Himmelstjerna, Georg Demeler, Janina Vanimisetti, Hima Bindu Bartram, David J. Denwood, Matthew J. Int J Parasitol Drugs Drug Resist Article Anthelmintic resistance has been increasingly reported in cattle worldwide over the last decade, although reports from Europe are more limited. The objective of the present study was to evaluate the efficacy of injectable formulations of ivermectin and moxidectin at 0.2 mg per kg bodyweight against naturally acquired gastro-intestinal nematodes in cattle. A total of 753 animals on 40 farms were enrolled in Germany (12 farms), the UK (10 farms), Italy (10 farms), and France (8 farms). Animals were selected based on pre-treatment faecal egg counts and were allocated to one of the two treatment groups. Each treatment group consisted of between 7 and 10 animals. A post-treatment faecal egg count was performed 14 days (±2 days) after treatment. The observed percentage reduction was calculated for each treatment group based on the arithmetic mean faecal egg count before and after treatment. The resistance status was evaluated based on the reduction in arithmetic mean faecal egg count and both the lower and upper 95% confidence limits. A decreased efficacy was observed in half or more of the farms in Germany, France and the UK. For moxidectin, resistance was confirmed on 3 farms in France, and on 1 farm in Germany and the UK. For ivermectin, resistance was confirmed on 3 farms in the UK, and on 1 farm in Germany and France. The remaining farms with decreased efficacy were classified as having an inconclusive resistance status based on the available data. After treatment Cooperia spp. larvae were most frequently identified, though Ostertagia ostertagi was also found, in particular within the UK and Germany. The present study reports lower than expected efficacy for ivermectin and moxidectin (based on the reduction in egg excretion after treatment) on European cattle farms, with confirmed anthelmintic resistance on 12.5% of the farms. Elsevier 2015-08-18 /pmc/articles/PMC4572401/ /pubmed/26448902 http://dx.doi.org/10.1016/j.ijpddr.2015.08.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Geurden, Thomas
Chartier, Christophe
Fanke, Jane
di Regalbono, Antonio Frangipane
Traversa, Donato
von Samson-Himmelstjerna, Georg
Demeler, Janina
Vanimisetti, Hima Bindu
Bartram, David J.
Denwood, Matthew J.
Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title_full Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title_fullStr Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title_full_unstemmed Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title_short Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe
title_sort anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in europe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572401/
https://www.ncbi.nlm.nih.gov/pubmed/26448902
http://dx.doi.org/10.1016/j.ijpddr.2015.08.001
work_keys_str_mv AT geurdenthomas anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT chartierchristophe anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT fankejane anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT diregalbonoantoniofrangipane anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT traversadonato anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT vonsamsonhimmelstjernageorg anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT demelerjanina anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT vanimisettihimabindu anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT bartramdavidj anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope
AT denwoodmatthewj anthelminticresistancetoivermectinandmoxidectiningastrointestinalnematodesofcattleineurope