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Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation

Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been perfor...

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Autores principales: Poldervaart, Rosalie A., Laging, Mirjam, Royaards, Tessa, Kal-van Gestel, Judith A., van Agteren, Madelon, de Klerk, Marry, Zuidema, Willij, Betjes, Michiel G. H., Roodnat, Joke I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572426/
https://www.ncbi.nlm.nih.gov/pubmed/26421181
http://dx.doi.org/10.1155/2015/748102
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author Poldervaart, Rosalie A.
Laging, Mirjam
Royaards, Tessa
Kal-van Gestel, Judith A.
van Agteren, Madelon
de Klerk, Marry
Zuidema, Willij
Betjes, Michiel G. H.
Roodnat, Joke I.
author_facet Poldervaart, Rosalie A.
Laging, Mirjam
Royaards, Tessa
Kal-van Gestel, Judith A.
van Agteren, Madelon
de Klerk, Marry
Zuidema, Willij
Betjes, Michiel G. H.
Roodnat, Joke I.
author_sort Poldervaart, Rosalie A.
collection PubMed
description Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been performed. In conventional and ABO-incompatible transplantation the willing donor becomes an actual donor for the intended recipient. In kidney-exchange and domino-donation the donor donates indirectly to the intended recipient. The relationship between the donor and intended recipient was studied. There were 935 conventional and 297 alternative program transplantations. There were 66 ABO-incompatible, 68 domino-paired, 62 kidney-exchange, and 104 altruistic donor transplantations. Waiting list recipients (n = 101) were excluded as they did not bring a living donor. 1131 couples remained of whom 196 participated in alternative programs. Genetically unrelated donors (486) were primarily partners. Genetically related donors (645) were siblings, parents, children, and others. Compared to genetically related couples, almost three times as many genetically unrelated couples were incompatible and participated in alternative programs (P < 0.001). 62% of couples were genetically related in the conventional donation program versus 32% in alternative programs (P < 0.001). Patient and graft survival were not significantly different between recipient programs. Alternative donation programs increase the number of transplantations by enabling genetically unrelated donors to donate.
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spelling pubmed-45724262015-09-29 Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation Poldervaart, Rosalie A. Laging, Mirjam Royaards, Tessa Kal-van Gestel, Judith A. van Agteren, Madelon de Klerk, Marry Zuidema, Willij Betjes, Michiel G. H. Roodnat, Joke I. J Transplant Research Article Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been performed. In conventional and ABO-incompatible transplantation the willing donor becomes an actual donor for the intended recipient. In kidney-exchange and domino-donation the donor donates indirectly to the intended recipient. The relationship between the donor and intended recipient was studied. There were 935 conventional and 297 alternative program transplantations. There were 66 ABO-incompatible, 68 domino-paired, 62 kidney-exchange, and 104 altruistic donor transplantations. Waiting list recipients (n = 101) were excluded as they did not bring a living donor. 1131 couples remained of whom 196 participated in alternative programs. Genetically unrelated donors (486) were primarily partners. Genetically related donors (645) were siblings, parents, children, and others. Compared to genetically related couples, almost three times as many genetically unrelated couples were incompatible and participated in alternative programs (P < 0.001). 62% of couples were genetically related in the conventional donation program versus 32% in alternative programs (P < 0.001). Patient and graft survival were not significantly different between recipient programs. Alternative donation programs increase the number of transplantations by enabling genetically unrelated donors to donate. Hindawi Publishing Corporation 2015 2015-09-02 /pmc/articles/PMC4572426/ /pubmed/26421181 http://dx.doi.org/10.1155/2015/748102 Text en Copyright © 2015 Rosalie A. Poldervaart et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Poldervaart, Rosalie A.
Laging, Mirjam
Royaards, Tessa
Kal-van Gestel, Judith A.
van Agteren, Madelon
de Klerk, Marry
Zuidema, Willij
Betjes, Michiel G. H.
Roodnat, Joke I.
Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title_full Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title_fullStr Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title_full_unstemmed Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title_short Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation
title_sort alternative living kidney donation programs boost genetically unrelated donation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572426/
https://www.ncbi.nlm.nih.gov/pubmed/26421181
http://dx.doi.org/10.1155/2015/748102
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