Cargando…

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

We tested whether DNA-methylation profiles account for inter-individual variation in body mass index (BMI) and height and whether they predict these phenotypes over and above genetic factors. Genetic predictors were derived from published summary results from the largest genome-wide association stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shah, Sonia, Bonder, Marc J., Marioni, Riccardo E., Zhu, Zhihong, McRae, Allan F., Zhernakova, Alexandra, Harris, Sarah E., Liewald, Dave, Henders, Anjali K., Mendelson, Michael M., Liu, Chunyu, Joehanes, Roby, Liang, Liming, Levy, Daniel, Martin, Nicholas G., Starr, John M., Wijmenga, Cisca, Wray, Naomi R., Yang, Jian, Montgomery, Grant W., Franke, Lude, Deary, Ian J., Visscher, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572498/ https://www.ncbi.nlm.nih.gov/pubmed/26119815 http://dx.doi.org/10.1016/j.ajhg.2015.05.014

Ejemplares similares

Genetic and environmental exposures constrain epigenetic drift over the human life course
por: Shah, Sonia, et al.
Publicado: (2014)

Identification of 55,000 Replicated DNA Methylation QTL
por: McRae, Allan F., et al.
Publicado: (2018)

Detection and replication of epistasis influencing transcription in humans
por: Hemani, Gibran, et al.
Publicado: (2014)

Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome
por: Zhernakova, Daria V., et al.
Publicado: (2018)

Genetic, parental and lifestyle factors influence telomere length
por: Andreu-Sánchez, Sergio, et al.
Publicado: (2022)

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels
por: Deelen, Patrick, et al.
Publicado: (2015)

No Evidence in a Large UK Collection for Celiac Disease Risk Variants Reported by a Spanish Study
por: Hunt, Karen A., et al.
Publicado: (2008)

DNA methylation age of blood predicts all-cause mortality in later life
por: Marioni, Riccardo E, et al.
Publicado: (2015)

The MHC locus and genetic susceptibility to autoimmune and infectious diseases
por: Matzaraki, Vasiliki, et al.
Publicado: (2017)

Relationship between gut microbiota and circulating metabolites in population-based cohorts
por: Vojinovic, Dina, et al.
Publicado: (2019)

Evaluation of European coeliac disease risk variants in a north Indian population
por: Senapati, Sabyasachi, et al.
Publicado: (2015)

Ciliary Genes Are Down-Regulated in Bronchial Tissue of Primary Ciliary Dyskinesia Patients
por: Geremek, Maciej, et al.
Publicado: (2014)

Shared genetic control of expression and methylation in peripheral blood
por: Shakhbazov, Konstantin, et al.
Publicado: (2016)

Genotype effects contribute to variation in longitudinal methylome patterns in older people
por: Zhang, Qian, et al.
Publicado: (2018)

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies
por: Hedman, Åsa K., et al.
Publicado: (2017)

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes
por: Mandaviya, Pooja R., et al.
Publicado: (2017)

Proton pump inhibitors affect the gut microbiome
por: Imhann, Floris, et al.
Publicado: (2016)

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids
por: Fu, Jingyuan, et al.
Publicado: (2015)

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes
por: Lopera Maya, Esteban A., et al.
Publicado: (2020)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2016)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
por: Marioni, Riccardo E, et al.
Publicado: (2018)

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
por: Wu, Yang, et al.
Publicado: (2018)

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
por: Qi, Ting, et al.
Publicado: (2018)

Seasonal Effects on Gene Expression
por: Goldinger, Anita, et al.
Publicado: (2015)

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data
por: Powell, Joseph E., et al.
Publicado: (2013)

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression
por: Kumar, Vinod, et al.
Publicado: (2013)

Studying the gut virome in the metagenomic era: challenges and perspectives
por: Garmaeva, Sanzhima, et al.
Publicado: (2019)

Contribution of genetic variation to transgenerational inheritance of DNA methylation
por: McRae, Allan F, et al.
Publicado: (2014)

Rare genetic variants underlie outlying levels of DNA methylation and gene-expression
por: Chundru, V Kartik, et al.
Publicado: (2023)

Detection of stable community structures within gut microbiota co-occurrence networks from different human populations
por: Jackson, Matthew A., et al.
Publicado: (2018)

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
por: Hillary, Robert F., et al.
Publicado: (2019)

The influence of a short-term gluten-free diet on the human gut microbiome
por: Bonder, Marc Jan, et al.
Publicado: (2016)

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity
por: Hrdlickova, Barbara, et al.
Publicado: (2014)

Genetic and epigenetic regulation of gene expression in fetal and adult human livers
por: Bonder, Marc Jan, et al.
Publicado: (2014)

OSCA: a tool for omic-data-based complex trait analysis
por: Zhang, Futao, et al.
Publicado: (2019)

The Brisbane Systems Genetics Study: Genetical Genomics Meets Complex Trait Genetics
por: Powell, Joseph E., et al.
Publicado: (2012)

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
por: Tigchelaar, Ettje F, et al.
Publicado: (2015)

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative
por: Wang, Jun, et al.
Publicado: (2018)

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
por: Jankipersadsing, Soesma A, et al.
Publicado: (2017)

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
por: Marioni, Riccardo E, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3g4d98m5hvqpncdebrfc5g00pt