Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA

Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of t...

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Detalles Bibliográficos
Autores principales: Hata, Kuniki, Urushibara, Ayumi, Yamashita, Shinichi, Lin, Mingzhang, Muroya, Yusa, Shikazono, Naoya, Yokoya, Akinari, Fu, Haiying, Katsumura, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572592/
https://www.ncbi.nlm.nih.gov/pubmed/25212600
http://dx.doi.org/10.1093/jrr/rru079

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