Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response

BACKGROUND: The genome-wide hyperacetylation of chromatin caused by histone deacetylase inhibitors (HDACi) is surprisingly well tolerated by most eukaryotic cells. The homeostatic mechanisms that underlie this tolerance are unknown. Here we identify the transcriptional and epigenomic changes that co...

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Detalles Bibliográficos
Autores principales: Halsall, John A, Turan, Nil, Wiersma, Maaike, Turner, Bryan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572612/
https://www.ncbi.nlm.nih.gov/pubmed/26380582
http://dx.doi.org/10.1186/s13072-015-0021-9

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