Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

BACKGROUND: Pallido-ponto-nigral degeneration (PPND), a major subtype of frontotemporal dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and terminal neurodegenerative disease caused by c.837 T > G mutation in the MAPT gene encoding microtubule-associated protein ta...

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Detalles Bibliográficos
Autores principales: Wren, Melissa C., Zhao, Jing, Liu, Chia-Chen, Murray, Melissa E., Atagi, Yuka, Davis, Mary D., Fu, Yuan, Okano, Hirotaka J., Ogaki, Kotaro, Strongosky, Audrey J., Tacik, Pawel, Rademakers, Rosa, Ross, Owen A., Dickson, Dennis W., Wszolek, Zbigniew K., Kanekiyo, Takahisa, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572645/
https://www.ncbi.nlm.nih.gov/pubmed/26373282
http://dx.doi.org/10.1186/s13024-015-0042-7

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