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Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells

BACKGROUND: The vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling pathway is involved in cancer-related biological functions and is a therapeutic target in cancer. However, the influence of epigenetic regulation of VEGF-VEGFR signaling-related genes remains unclear. Here, we...

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Detalles Bibliográficos
Autores principales:	Kim, Jee Yeon, Hwang, Junha, Lee, Seo Hyun, Lee, Hyo Jin, Jelinek, Jaroslav, Jeong, Hyeseon, Lim, Jae Sung, Kim, Jin Man, Song, Kyu Sang, Kim, Byung Hoon, Lee, Sukhoon, Kim, Jei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572656/ https://www.ncbi.nlm.nih.gov/pubmed/26380584 http://dx.doi.org/10.1186/s13148-015-0134-9

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