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Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins
Streptomyces sp. TP-A0598, isolated from seawater, produces lydicamycin, structurally unique type I polyketide bearing two nitrogen-containing five-membered rings, and four congeners TPU-0037-A, −B, −C, and –D. We herein report the 8 Mb draft genome sequence of this strain, together with classificat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572681/ https://www.ncbi.nlm.nih.gov/pubmed/26380643 http://dx.doi.org/10.1186/s40793-015-0046-5 |
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author | Komaki, Hisayuki Ichikawa, Natsuko Hosoyama, Akira Fujita, Nobuyuki Igarashi, Yasuhiro |
author_facet | Komaki, Hisayuki Ichikawa, Natsuko Hosoyama, Akira Fujita, Nobuyuki Igarashi, Yasuhiro |
author_sort | Komaki, Hisayuki |
collection | PubMed |
description | Streptomyces sp. TP-A0598, isolated from seawater, produces lydicamycin, structurally unique type I polyketide bearing two nitrogen-containing five-membered rings, and four congeners TPU-0037-A, −B, −C, and –D. We herein report the 8 Mb draft genome sequence of this strain, together with classification and features of the organism and generation, annotation and analysis of the genome sequence. The genome encodes 7,240 putative ORFs, of which 4,450 ORFs were assigned with COG categories. Also, 66 tRNA genes and one rRNA operon were identified. The genome contains eight gene clusters involved in the production of polyketides and nonribosomal peptides. Among them, a PKS/NRPS gene cluster was assigned to be responsible for lydicamycin biosynthesis and a plausible biosynthetic pathway was proposed on the basis of gene function prediction. This genome sequence data will facilitate to probe the potential of secondary metabolism in marine-derived Streptomyces. |
format | Online Article Text |
id | pubmed-4572681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45726812015-09-18 Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins Komaki, Hisayuki Ichikawa, Natsuko Hosoyama, Akira Fujita, Nobuyuki Igarashi, Yasuhiro Stand Genomic Sci Extended Genome Report Streptomyces sp. TP-A0598, isolated from seawater, produces lydicamycin, structurally unique type I polyketide bearing two nitrogen-containing five-membered rings, and four congeners TPU-0037-A, −B, −C, and –D. We herein report the 8 Mb draft genome sequence of this strain, together with classification and features of the organism and generation, annotation and analysis of the genome sequence. The genome encodes 7,240 putative ORFs, of which 4,450 ORFs were assigned with COG categories. Also, 66 tRNA genes and one rRNA operon were identified. The genome contains eight gene clusters involved in the production of polyketides and nonribosomal peptides. Among them, a PKS/NRPS gene cluster was assigned to be responsible for lydicamycin biosynthesis and a plausible biosynthetic pathway was proposed on the basis of gene function prediction. This genome sequence data will facilitate to probe the potential of secondary metabolism in marine-derived Streptomyces. BioMed Central 2015-08-26 /pmc/articles/PMC4572681/ /pubmed/26380643 http://dx.doi.org/10.1186/s40793-015-0046-5 Text en © Komaki et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Extended Genome Report Komaki, Hisayuki Ichikawa, Natsuko Hosoyama, Akira Fujita, Nobuyuki Igarashi, Yasuhiro Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title | Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title_full | Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title_fullStr | Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title_full_unstemmed | Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title_short | Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins |
title_sort | draft genome sequence of marine-derived streptomyces sp. tp-a0598, a producer of anti-mrsa antibiotic lydicamycins |
topic | Extended Genome Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572681/ https://www.ncbi.nlm.nih.gov/pubmed/26380643 http://dx.doi.org/10.1186/s40793-015-0046-5 |
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