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Balance impairment and systemic inflammation in chronic obstructive pulmonary disease

BACKGROUND/PURPOSE: Chronic obstructive pulmonary disease (COPD), especially in severe forms, is commonly associated with systemic inflammation and balance impairment. The aim of our study was to evaluate the impact on equilibrium of stable and exacerbation (acute exacerbation of COPD [AECOPD]) phas...

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Autores principales: Tudorache, Emanuela, Oancea, Cristian, Avram, Claudiu, Fira-Mladinescu, Ovidiu, Petrescu, Lucian, Timar, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572735/
https://www.ncbi.nlm.nih.gov/pubmed/26392759
http://dx.doi.org/10.2147/COPD.S89814
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author Tudorache, Emanuela
Oancea, Cristian
Avram, Claudiu
Fira-Mladinescu, Ovidiu
Petrescu, Lucian
Timar, Bogdan
author_facet Tudorache, Emanuela
Oancea, Cristian
Avram, Claudiu
Fira-Mladinescu, Ovidiu
Petrescu, Lucian
Timar, Bogdan
author_sort Tudorache, Emanuela
collection PubMed
description BACKGROUND/PURPOSE: Chronic obstructive pulmonary disease (COPD), especially in severe forms, is commonly associated with systemic inflammation and balance impairment. The aim of our study was to evaluate the impact on equilibrium of stable and exacerbation (acute exacerbation of COPD [AECOPD]) phases of COPD and to investigate if there is a connection between lower extremity muscle weakness and systemic inflammation. METHODS: We enrolled 41 patients with COPD (22 stable and 19 in AECOPD) and 20 healthy subjects (control group), having no significant differences regarding the anthropometric data. We analyzed the differences in balance tests scores: Falls Efficacy Scale-International (FES-I) questionnaire, Berg Balance Scale (BBS), Timed Up and Go (TUG) test, Single Leg Stance (SLS), 6-minute walking distance (6MWD), isometric knee extension (IKE) between these groups, and also the correlation between these scores and inflammatory biomarkers. RESULTS: The presence and severity of COPD was associated with significantly decreased score in IKE (P<0.001), 6MWD (P<0.001), SLS (P<0.001), and BBS (P<0.001), at the same time noting a significant increase in median TUG score across the studied groups (P<0.001). The AECOPD group vs stable group presented a significant increase in high-sensitive C-reactive protein (hs-CRP) levels (10.60 vs 4.01; P=0.003) and decrease in PaO(2) (70.1 vs 59.1; P<0.001). We observed that both IKE scores were significantly and positive correlated with all the respiratory volumes. In both COPD groups, we observed that fibrinogen reversely and significantly correlated with the 6MWD, and FES-I questionnaire is correlated positively with TUG test. Hs-CRP correlated reversely with the walking test and SLS test, while correlating positively with TUG test and FES-I questionnaire. CONCLUSION: According to this study, COPD in advanced and acute stages is associated with an increased history of falls, systemic inflammation, balance impairment, and lower extremity muscle weakness.
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spelling pubmed-45727352015-09-21 Balance impairment and systemic inflammation in chronic obstructive pulmonary disease Tudorache, Emanuela Oancea, Cristian Avram, Claudiu Fira-Mladinescu, Ovidiu Petrescu, Lucian Timar, Bogdan Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND/PURPOSE: Chronic obstructive pulmonary disease (COPD), especially in severe forms, is commonly associated with systemic inflammation and balance impairment. The aim of our study was to evaluate the impact on equilibrium of stable and exacerbation (acute exacerbation of COPD [AECOPD]) phases of COPD and to investigate if there is a connection between lower extremity muscle weakness and systemic inflammation. METHODS: We enrolled 41 patients with COPD (22 stable and 19 in AECOPD) and 20 healthy subjects (control group), having no significant differences regarding the anthropometric data. We analyzed the differences in balance tests scores: Falls Efficacy Scale-International (FES-I) questionnaire, Berg Balance Scale (BBS), Timed Up and Go (TUG) test, Single Leg Stance (SLS), 6-minute walking distance (6MWD), isometric knee extension (IKE) between these groups, and also the correlation between these scores and inflammatory biomarkers. RESULTS: The presence and severity of COPD was associated with significantly decreased score in IKE (P<0.001), 6MWD (P<0.001), SLS (P<0.001), and BBS (P<0.001), at the same time noting a significant increase in median TUG score across the studied groups (P<0.001). The AECOPD group vs stable group presented a significant increase in high-sensitive C-reactive protein (hs-CRP) levels (10.60 vs 4.01; P=0.003) and decrease in PaO(2) (70.1 vs 59.1; P<0.001). We observed that both IKE scores were significantly and positive correlated with all the respiratory volumes. In both COPD groups, we observed that fibrinogen reversely and significantly correlated with the 6MWD, and FES-I questionnaire is correlated positively with TUG test. Hs-CRP correlated reversely with the walking test and SLS test, while correlating positively with TUG test and FES-I questionnaire. CONCLUSION: According to this study, COPD in advanced and acute stages is associated with an increased history of falls, systemic inflammation, balance impairment, and lower extremity muscle weakness. Dove Medical Press 2015-09-08 /pmc/articles/PMC4572735/ /pubmed/26392759 http://dx.doi.org/10.2147/COPD.S89814 Text en © 2015 Tudorache et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Tudorache, Emanuela
Oancea, Cristian
Avram, Claudiu
Fira-Mladinescu, Ovidiu
Petrescu, Lucian
Timar, Bogdan
Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title_full Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title_fullStr Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title_full_unstemmed Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title_short Balance impairment and systemic inflammation in chronic obstructive pulmonary disease
title_sort balance impairment and systemic inflammation in chronic obstructive pulmonary disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572735/
https://www.ncbi.nlm.nih.gov/pubmed/26392759
http://dx.doi.org/10.2147/COPD.S89814
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