Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

OBJECTIVE: Thrombin has multiple proatherogenic effects including platelet activation and the induction of inflammatory processes. Recently, the cytokine oncostatin M has been shown to have proinflammatory effects. This study was designed to investigate the effects of thrombin inhibition on the init...

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Detalles Bibliográficos
Autores principales: Preusch, Michael R, Ieronimakis, Nicholas, Wijelath, Errol S, Cabbage, Sara, Ricks, Jerry, Bea, Florian, Reyes, Morayma, van Ryn, Joanne, Rosenfeld, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572747/
https://www.ncbi.nlm.nih.gov/pubmed/26392754
http://dx.doi.org/10.2147/DDDT.S86969

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