Suppression of epithelial–mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells

The embryonic stem cell (ESC)-enriched miR-294/302 family and the somatic cell-enriched let-7 family stabilizes the self-renewing and differentiated cell fates, respectively. The mechanisms underlying these processes remain unknown. Here we show that among many pathways regulated by miR-294/302, the...

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Detalles Bibliográficos
Autores principales: Guo, W-T, Wang, X-W, Yan, Y-L, Li, Y-P, Yin, X, Zhang, Q, Melton, C, Shenoy, A, Reyes, N A, Oakes, S A, Blelloch, R, Wang, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572863/
https://www.ncbi.nlm.nih.gov/pubmed/25501598
http://dx.doi.org/10.1038/cdd.2014.205

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