A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

Increasing evidence indicates that metabolism is implicated in the control of stem cell identity. Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2α-Atf4 amino acid s...

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Detalles Bibliográficos
Autores principales: D'Aniello, C, Fico, A, Casalino, L, Guardiola, O, Di Napoli, G, Cermola, F, De Cesare, D, Tatè, R, Cobellis, G, Patriarca, E J, Minchiotti, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572871/
https://www.ncbi.nlm.nih.gov/pubmed/25857264
http://dx.doi.org/10.1038/cdd.2015.24

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