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Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development
No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibu...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573071/ https://www.ncbi.nlm.nih.gov/pubmed/26392753 http://dx.doi.org/10.2147/DDDT.S85435 |