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Comparison of single-dose and multiple-dose pharmacokinetics between two formulations of hydrocodone bitartrate/acetaminophen: immediate-release versus biphasic immediate-release/extended release

OBJECTIVE: This study aimed to compare the single-dose and steady-state pharmacokinetics (PK) of biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) and IR HB/APAP. SETTING: The study was conducted in a contract research center. PARTICIPANTS: The st...

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Detalles Bibliográficos
Autores principales: Devarakonda, Krishna, Kostenbader, Kenneth, Giuliani, Michael J, Young, Jim L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573203/
https://www.ncbi.nlm.nih.gov/pubmed/26392786
http://dx.doi.org/10.2147/JPR.S79578