Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice

We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mi...

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Detalles Bibliográficos
Autores principales: Wright, Tyler T, Jimenez, Rachel V., Morgan, Todd E., Bali, Namrata, Hou, Xiaogang, McCrory, Mark A., Finch, Caleb E., Szalai, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573232/
https://www.ncbi.nlm.nih.gov/pubmed/26421184
http://dx.doi.org/10.1155/2015/640171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573232/
https://www.ncbi.nlm.nih.gov/pubmed/26421184
http://dx.doi.org/10.1155/2015/640171

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