Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

Del-1 is an endothelial cell-secreted anti-inflammatory protein. In humans and mice, Del-1 expression is inversely related to that of IL-17, which inhibits Del-1 through hitherto unidentified mechanism(s). Here we show that IL-17 downregulates human endothelial cell expression of Del-1 by targeting...

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Detalles Bibliográficos
Autores principales: Maekawa, Tomoki, Hosur, Kavita, Abe, Toshiharu, Kantarci, Alpdogan, Ziogas, Athanasios, Wang, Baomei, Van Dyke, Thomas E., Chavakis, Triantafyllos, Hajishengallis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573473/
https://www.ncbi.nlm.nih.gov/pubmed/26374165
http://dx.doi.org/10.1038/ncomms9272

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