Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review

Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in t...

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Detalles Bibliográficos
Autores principales: Kamar, Fareed B., McQuillan, Rory F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573617/
https://www.ncbi.nlm.nih.gov/pubmed/26425378
http://dx.doi.org/10.1155/2015/309791
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author Kamar, Fareed B.
McQuillan, Rory F.
author_facet Kamar, Fareed B.
McQuillan, Rory F.
author_sort Kamar, Fareed B.
collection PubMed
description Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in this report of an adult male with concomitant acute kidney injury. This case emphasizes the caution that must be taken in prescribing cholestyramine to patients who may also be volume depleted, in renal failure, or taking spironolactone.
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spelling pubmed-45736172015-09-30 Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review Kamar, Fareed B. McQuillan, Rory F. Case Rep Nephrol Case Report Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in this report of an adult male with concomitant acute kidney injury. This case emphasizes the caution that must be taken in prescribing cholestyramine to patients who may also be volume depleted, in renal failure, or taking spironolactone. Hindawi Publishing Corporation 2015 2015-09-03 /pmc/articles/PMC4573617/ /pubmed/26425378 http://dx.doi.org/10.1155/2015/309791 Text en Copyright © 2015 F. B. Kamar and R. F. McQuillan. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kamar, Fareed B.
McQuillan, Rory F.
Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title_full Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title_fullStr Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title_full_unstemmed Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title_short Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
title_sort hyperchloremic metabolic acidosis due to cholestyramine: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573617/
https://www.ncbi.nlm.nih.gov/pubmed/26425378
http://dx.doi.org/10.1155/2015/309791
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