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Functions and regulation of the multitasking FANCM family of DNA motor proteins
Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573851/ https://www.ncbi.nlm.nih.gov/pubmed/26341555 http://dx.doi.org/10.1101/gad.266593.115 |
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author | Xue, Xiaoyu Sung, Patrick Zhao, Xiaolan |
author_facet | Xue, Xiaoyu Sung, Patrick Zhao, Xiaolan |
author_sort | Xue, Xiaoyu |
collection | PubMed |
description | Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes. |
format | Online Article Text |
id | pubmed-4573851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45738512016-03-01 Functions and regulation of the multitasking FANCM family of DNA motor proteins Xue, Xiaoyu Sung, Patrick Zhao, Xiaolan Genes Dev Review Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes. Cold Spring Harbor Laboratory Press 2015-09-01 /pmc/articles/PMC4573851/ /pubmed/26341555 http://dx.doi.org/10.1101/gad.266593.115 Text en © 2015 Xue et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Xue, Xiaoyu Sung, Patrick Zhao, Xiaolan Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title_full | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title_fullStr | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title_full_unstemmed | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title_short | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
title_sort | functions and regulation of the multitasking fancm family of dna motor proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573851/ https://www.ncbi.nlm.nih.gov/pubmed/26341555 http://dx.doi.org/10.1101/gad.266593.115 |
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