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Functions and regulation of the multitasking FANCM family of DNA motor proteins

Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic f...

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Detalles Bibliográficos
Autores principales: Xue, Xiaoyu, Sung, Patrick, Zhao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573851/
https://www.ncbi.nlm.nih.gov/pubmed/26341555
http://dx.doi.org/10.1101/gad.266593.115
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author Xue, Xiaoyu
Sung, Patrick
Zhao, Xiaolan
author_facet Xue, Xiaoyu
Sung, Patrick
Zhao, Xiaolan
author_sort Xue, Xiaoyu
collection PubMed
description Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes.
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spelling pubmed-45738512016-03-01 Functions and regulation of the multitasking FANCM family of DNA motor proteins Xue, Xiaoyu Sung, Patrick Zhao, Xiaolan Genes Dev Review Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes. Cold Spring Harbor Laboratory Press 2015-09-01 /pmc/articles/PMC4573851/ /pubmed/26341555 http://dx.doi.org/10.1101/gad.266593.115 Text en © 2015 Xue et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Xue, Xiaoyu
Sung, Patrick
Zhao, Xiaolan
Functions and regulation of the multitasking FANCM family of DNA motor proteins
title Functions and regulation of the multitasking FANCM family of DNA motor proteins
title_full Functions and regulation of the multitasking FANCM family of DNA motor proteins
title_fullStr Functions and regulation of the multitasking FANCM family of DNA motor proteins
title_full_unstemmed Functions and regulation of the multitasking FANCM family of DNA motor proteins
title_short Functions and regulation of the multitasking FANCM family of DNA motor proteins
title_sort functions and regulation of the multitasking fancm family of dna motor proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573851/
https://www.ncbi.nlm.nih.gov/pubmed/26341555
http://dx.doi.org/10.1101/gad.266593.115
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