Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation

The eIF4E-binding proteins (4E-BPs) are a diverse class of translation regulators that share a canonical eIF4E-binding motif (4E-BM) with eIF4G. Consequently, they compete with eIF4G for binding to eIF4E, thereby inhibiting translation initiation. Mextli (Mxt) is an unusual 4E-BP that promotes trans...

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Detalles Bibliográficos
Autores principales: Peter, Daniel, Weber, Ramona, Köne, Carolin, Chung, Min-Yi, Ebertsch, Linda, Truffault, Vincent, Weichenrieder, Oliver, Igreja, Cátia, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573856/
https://www.ncbi.nlm.nih.gov/pubmed/26294658
http://dx.doi.org/10.1101/gad.269068.115

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