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Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition

The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements. The fundamental basis of the system is the ability to capture small pieces of foreign DNA for incorporation into the genome at the CRISPR locus, a process known as Adaptation, which is...

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Detalles Bibliográficos
Autores principales: Rollie, Clare, Schneider, Stefanie, Brinkmann, Anna Sophie, Bolt, Edward L, White, Malcolm F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574026/
https://www.ncbi.nlm.nih.gov/pubmed/26284603
http://dx.doi.org/10.7554/eLife.08716