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Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans

BACKGROUND: The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6-n-propylthiouracial (PROP). There are two common haplotypes of this gene, the recessive AVI and the dominant PAV, both of which are well studied. Conversely, the ro...

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Autores principales: Boxer, Emma E., Garneau, Nicole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574037/
https://www.ncbi.nlm.nih.gov/pubmed/26405625
http://dx.doi.org/10.1186/s40064-015-1277-z
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author Boxer, Emma E.
Garneau, Nicole L.
author_facet Boxer, Emma E.
Garneau, Nicole L.
author_sort Boxer, Emma E.
collection PubMed
description BACKGROUND: The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6-n-propylthiouracial (PROP). There are two common haplotypes of this gene, the recessive AVI and the dominant PAV, both of which are well studied. Conversely, the role of rare TAS2R38 haplotypes on bitter taste sensitivity has been notoriously difficult to study due to small sample sizes. Here we present PROP sensitivity data of 97 individuals that have been observed to carry rare haplotypes (AAV, AAI, PAI, PVI) of the TAS2R38 gene. RESULTS: Participants rated their bitter taste perception to a PROP filter disc then provided a buccal DNA sample from which the TAS2R38 gene was sequenced and analyzed. We found the prevalence of the PAV haplotype to be 42.3 %, AVI 53.1 %, AAV 2.5 %, AAI 1.2 %, PAI 0.8 % and PVI 0.1 %. We found that the AAI, AAV, and PAI haplotypes present intermediate taste sensitivity. CONCLUSIONS: These data are further evidence that bitter taste sensitivity to PROP exists as a broad range, and not exclusively as nontasters, medium tasters, and supertasters.
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spelling pubmed-45740372015-09-24 Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans Boxer, Emma E. Garneau, Nicole L. Springerplus Short Report BACKGROUND: The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6-n-propylthiouracial (PROP). There are two common haplotypes of this gene, the recessive AVI and the dominant PAV, both of which are well studied. Conversely, the role of rare TAS2R38 haplotypes on bitter taste sensitivity has been notoriously difficult to study due to small sample sizes. Here we present PROP sensitivity data of 97 individuals that have been observed to carry rare haplotypes (AAV, AAI, PAI, PVI) of the TAS2R38 gene. RESULTS: Participants rated their bitter taste perception to a PROP filter disc then provided a buccal DNA sample from which the TAS2R38 gene was sequenced and analyzed. We found the prevalence of the PAV haplotype to be 42.3 %, AVI 53.1 %, AAV 2.5 %, AAI 1.2 %, PAI 0.8 % and PVI 0.1 %. We found that the AAI, AAV, and PAI haplotypes present intermediate taste sensitivity. CONCLUSIONS: These data are further evidence that bitter taste sensitivity to PROP exists as a broad range, and not exclusively as nontasters, medium tasters, and supertasters. Springer International Publishing 2015-09-17 /pmc/articles/PMC4574037/ /pubmed/26405625 http://dx.doi.org/10.1186/s40064-015-1277-z Text en © Boxer and Garneau. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Report
Boxer, Emma E.
Garneau, Nicole L.
Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title_full Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title_fullStr Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title_full_unstemmed Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title_short Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans
title_sort rare haplotypes of the gene tas2r38 confer bitter taste sensitivity in humans
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574037/
https://www.ncbi.nlm.nih.gov/pubmed/26405625
http://dx.doi.org/10.1186/s40064-015-1277-z
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