Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WD...

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Detalles Bibliográficos
Autores principales: Kodani, Andrew, Yu, Timothy W, Johnson, Jeffrey R, Jayaraman, Divya, Johnson, Tasha L, Al-Gazali, Lihadh, Sztriha, Lāszló, Partlow, Jennifer N, Kim, Hanjun, Krup, Alexis L, Dammermann, Alexander, Krogan, Nevan J, Walsh, Christopher A, Reiter, Jeremy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574112/
https://www.ncbi.nlm.nih.gov/pubmed/26297806
http://dx.doi.org/10.7554/eLife.07519

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