Cargando…

Pharmacophore Modeling and Molecular Docking Studies of potential inhibitors to E6 PBM–PDZ from Human Papilloma Virus (HPV)

High-risk human papillomaviruses (HPVs) are known to cause cervical cancer. Vaccines are now available to prevent HPV infection. However, a clinically approved drug is yet not available to treat HPV. The PDZ(PSD−95/Dlg/ZO−1)−binding motif (PBM) in the E6 protein of HPVs targets the PDZ domain (known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Yu-Shi, Kawashita, Norihito, Arai, Yuki, Okamoto, Kousuke, Takagi, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2015
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574123/ https://www.ncbi.nlm.nih.gov/pubmed/26420921 http://dx.doi.org/10.6026/97320630011401

Ejemplares similares

Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors
por: Radwan, Awwad Abdoh
Publicado: (2015)

E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR)
por: Nagamani, Selvaraman, et al.
Publicado: (2012)

Molecular docking and pharmacophore studies of heterocyclic compounds as Heat shock protein 90 (Hsp90) Inhibitors
por: Baby, Suby T, et al.
Publicado: (2016)

Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations
por: Chauhan, Navneet, et al.
Publicado: (2016)

Pharmacophore and Virtual Screening of JAK3 inhibitors
por: Rajeswari, Murugesan, et al.
Publicado: (2014)

Lead identification and optimization of novel collagenase inhibitors; pharmacophore and structure based studies
por: Kalva, Sukesh, et al.
Publicado: (2012)

Nilotinib based pharmacophore models for BCRABL
por: Sabitha, Kesavan
Publicado: (2012)

Computational screening of inhibitors for HIV-1 integrase using a receptor based pharmacophore model
por: Jaganatharaja, Janani, et al.
Publicado: (2006)

Virtual screening and pharmacophore studies for ftase inhibitors using Indian plant anticancer compounds database
por: Khan, Abdul Hafeez, et al.
Publicado: (2010)

Computer aided screening of natural compounds targeting the E6 protein of HPV using molecular docking
por: Mamgain, Saril, et al.
Publicado: (2015)

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site
por: Singh, Durg Vijay, et al.
Publicado: (2009)

Linear epitope prediction in HPV type 16 E7 antigen and their docked interaction with human TMEM 50A structural model
por: Srivastava, Upasna, et al.
Publicado: (2017)

Lead expansion and virtual screening of Indinavir derivate HIV-1 protease inhibitors using pharmacophoric - shape similarity scoring function
por: Shityakov, Sergey, et al.
Publicado: (2010)

Discovery of novel low-molecular-weight HIV-1 inhibitors interacting with cyclophilin A using in silico screening and biological evaluations
por: Tian, Yu-Shi, et al.
Publicado: (2012)

Molecular docking based screening of Noggin inhibitors
por: Gudipati, Sindhura, et al.
Publicado: (2018)

Virtual screening of RAGE inhibitors using molecular docking
por: Devi Alaparthi, Malini, et al.
Publicado: (2016)

Molecular docking studies on DMDP derivatives as human DHFR inhibitors
por: Srivastava, Vivek, et al.
Publicado: (2008)

Molecular docking based screening of Listeriolysin-O for improved inhibitors
por: Ghafari, Sara, et al.
Publicado: (2017)

Comparative molecular docking analysis of essential oil constituents as elastase inhibitors
por: Sivamani, Periyasamy, et al.
Publicado: (2012)

Molecular modeling and docking of small molecule inhibitors against NEK2
por: Ramachandran, Balaji, et al.
Publicado: (2016)

Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors
por: Srivastava, Vivek, et al.
Publicado: (2010)

Molecular Docking Based Screening of Plant Flavonoids as Dengue NS1 Inhibitors
por: Qamar, Muhammad Tahir ul, et al.
Publicado: (2014)

Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor
por: Akare, Uday Raj, et al.
Publicado: (2014)

Molecular screening and docking analysis of LMTK3and AKT1 combined inhibitors
por: Allam, Loubna, et al.
Publicado: (2018)

Structure based virtual screening to identify inhibitors against MurE Enzyme of Mycobacterium tuberculosis using AutoDock Vina
por: Singh, Shilpi, et al.
Publicado: (2014)

Molecular modelling, docking and interaction studies of human-plasmogen and salmonella enolase with enolase inhibitors
por: Chauhan, Digvijay Singh, et al.
Publicado: (2012)

Identification of small molecule inhibitors against UBE2C by using docking studies
por: Sabitha, Kesavan, et al.
Publicado: (2012)

Molecular docking based screening of GABA (A) receptor inhibitors from plant derivatives
por: Sahila, Mohammed Marunnan, et al.
Publicado: (2015)

Molecular Docking studies of FKBP12-mTOR inhibitors using binding predictions
por: Nasr, Arash Boroumand, et al.
Publicado: (2015)

Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer
por: Dash, Raju, et al.
Publicado: (2015)

Structurebased drug design and AutoDock study of potential protein tyrosine kinase inhibitors.
por: Ali, Hamed Ismail, et al.
Publicado: (2011)

Molecular docking based screening of predicted potential inhibitors for VP40 from Ebola virus
por: Abazari, Danya, et al.
Publicado: (2015)

Shape based virtual screening and molecular docking towards designing novel pancreatic lipase inhibitors
por: Veeramachaneni, Ganesh Kumar, et al.
Publicado: (2015)

Molecular docking based screening of a simulated HIF-1 protein model for potential inhibitors
por: Latha, Mundla Sri, et al.
Publicado: (2017)

High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer
por: Gao, Peng, et al.
Publicado: (2010)

Epitope design of L1 protein for vaccine production against Human Papilloma Virus types 16 and 18
por: Baidya, Sunanda, et al.
Publicado: (2017)

Molecular docking study of P4-Benzoxaborolesubstituted ligands as inhibitors of HCV NS3/4A protease
por: Wadood, Abdul, et al.
Publicado: (2013)

Molecular docking studies of benzimidazopyrimidine and coumarin substituted benzimidazopyrimidine derivatives: As potential human Aurora A kinase inhibitors
por: Chandra,, et al.
Publicado: (2014)

Molecular docking of 1H-pyrazole derivatives to receptor tyrosine kinase and protein kinase for screening potential inhibitors
por: Chandra,, et al.
Publicado: (2014)

Molecular docking and virtual screening for novel protein tyrosine phosphatase 1B (PTP1B) inhibitors
por: Rao, Pasupuleti Sreenivasa, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_73v3r8ogthujvq82iu7iu24dh1