Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells

BACKGROUND & METHODS: Recombinant factor VII (rFVII), the precursor molecule for recombinant activated FVII (rFVIIa), is, due to its need for complex post translational modifications, produced in mammalian cells. To evaluate the suitability of a human cell line in order to produce rFVII with pos...

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Detalles Bibliográficos
Autores principales: Böhm, Ernst, Seyfried, Birgit K., Dockal, Michael, Graninger, Michael, Hasslacher, Meinhard, Neurath, Marianne, Konetschny, Christian, Matthiessen, Peter, Mitterer, Artur, Scheiflinger, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574471/
https://www.ncbi.nlm.nih.gov/pubmed/26382581
http://dx.doi.org/10.1186/s12896-015-0205-1

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