High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer

BACKGROUND: Cancer is caused by somatic DNA alterations such as gene point mutations, DNA copy number aberrations (CNA) and structural variants (SVs). Genome-wide analyses of SVs in large sample series with well-documented clinical information are still scarce. Consequently, the impact of SVs on car...

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Detalles Bibliográficos
Autores principales: van den Broek, Evert, Dijkstra, Maurits J. J., Krijgsman, Oscar, Sie, Daoud, Haan, Josien C., Traets, Joleen J. H., van de Wiel, Mark A., Nagtegaal, Iris D., Punt, Cornelis J. A., Carvalho, Beatriz, Ylstra, Bauke, Abeln, Sanne, Meijer, Gerrit A., Fijneman, Remond J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574474/
https://www.ncbi.nlm.nih.gov/pubmed/26375816
http://dx.doi.org/10.1371/journal.pone.0138141

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