Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide

Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superp...

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Autores principales: Alam, Shirjel R., Stirrat, Colin, Richards, Jennifer, Mirsadraee, Saeed, Semple, Scott I. K., Tse, George, Henriksen, Peter, Newby, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574723/
https://www.ncbi.nlm.nih.gov/pubmed/26381872
http://dx.doi.org/10.1186/s12968-015-0183-4
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author Alam, Shirjel R.
Stirrat, Colin
Richards, Jennifer
Mirsadraee, Saeed
Semple, Scott I. K.
Tse, George
Henriksen, Peter
Newby, David E.
author_facet Alam, Shirjel R.
Stirrat, Colin
Richards, Jennifer
Mirsadraee, Saeed
Semple, Scott I. K.
Tse, George
Henriksen, Peter
Newby, David E.
author_sort Alam, Shirjel R.
collection PubMed
description Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.
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spelling pubmed-45747232015-09-23 Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide Alam, Shirjel R. Stirrat, Colin Richards, Jennifer Mirsadraee, Saeed Semple, Scott I. K. Tse, George Henriksen, Peter Newby, David E. J Cardiovasc Magn Reson Review Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease. BioMed Central 2015-09-18 /pmc/articles/PMC4574723/ /pubmed/26381872 http://dx.doi.org/10.1186/s12968-015-0183-4 Text en © Alam et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Alam, Shirjel R.
Stirrat, Colin
Richards, Jennifer
Mirsadraee, Saeed
Semple, Scott I. K.
Tse, George
Henriksen, Peter
Newby, David E.
Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title_full Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title_fullStr Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title_full_unstemmed Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title_short Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
title_sort vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574723/
https://www.ncbi.nlm.nih.gov/pubmed/26381872
http://dx.doi.org/10.1186/s12968-015-0183-4
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