Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to treatment. To overcome this limitation, we screene...

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Detalles Bibliográficos
Autores principales: Reddy, Anupama, Growney, Joseph D., Wilson, Nick S., Emery, Caroline M., Johnson, Jennifer A., Ward, Rebecca, Monaco, Kelli A., Korn, Joshua, Monahan, John E., Stump, Mark D., Mapa, Felipa A., Wilson, Christopher J., Steiger, Janine, Ledell, Jebediah, Rickles, Richard J., Myer, Vic E., Ettenberg, Seth A., Schlegel, Robert, Sellers, William R., Huet, Heather A., Lehár, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574744/
https://www.ncbi.nlm.nih.gov/pubmed/26378449
http://dx.doi.org/10.1371/journal.pone.0138486

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