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Poly(U) RNA-templated synthesis of AppA

Simple nucleotide templating activities are of interest as potential primordial reactions. Here we describe the acceleration of 5′-5′ AppA synthesis by 3′-5′ poly(U) under normal solution conditions. This reaction is apparently templated via complementary U:A base-pairing, despite the involvement of...

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Detalles Bibliográficos
Autores principales: Puthenvedu, Deepa, Janas, Teresa, Majerfeld, Irene, Illangasekare, Mali, Yarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574757/
https://www.ncbi.nlm.nih.gov/pubmed/26272215
http://dx.doi.org/10.1261/rna.052696.115