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Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer
Growing evidences show that matrix metalloproteinase-1 (MMP1) plays important roles in tumorigenesis and cancer metastasis. The interactions between MMP1−1607 1G>2G polymorphism and risk of gastric cancer (GC) have been reported, but results remained ambiguous. To determine the association betwee...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574801/ https://www.ncbi.nlm.nih.gov/pubmed/26392779 http://dx.doi.org/10.2147/OTT.S83004 |
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author | Peng, Qisong Xu, Yong |
author_facet | Peng, Qisong Xu, Yong |
author_sort | Peng, Qisong |
collection | PubMed |
description | Growing evidences show that matrix metalloproteinase-1 (MMP1) plays important roles in tumorigenesis and cancer metastasis. The interactions between MMP1−1607 1G>2G polymorphism and risk of gastric cancer (GC) have been reported, but results remained ambiguous. To determine the association between MMP1−1607 1G>2G polymorphism and risk of GC, we conducted a meta-analysis and identified the outcome data from all the research papers estimating the association between MMP1−1607 1G>2G polymorphism and GC risk, which was based on comprehensive searches using databases such as PubMed, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Chinese National Knowledge Infrastructure (CNKI). The fixed-effects model was used in this meta-analysis. Data were extracted, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. In this meta-analysis, six studies involving 1,377 cases and 1,543 controls were included. We identified the significant association between MMP1−1607 1G>2G polymorphism and GC risk for allele model (OR =1.05; 95% CI, 1.01−1.08), for dominant model (OR =1.11; 95% CI, 1.08−1.15), and for recessive model (OR =1.06; 95% CI, 0.98−1.14). In summary, our analysis demonstrated that MMP1−1607 1G>2G polymorphism was significantly associated with an increased risk of GC. |
format | Online Article Text |
id | pubmed-4574801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45748012015-09-21 Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer Peng, Qisong Xu, Yong Onco Targets Ther Original Research Growing evidences show that matrix metalloproteinase-1 (MMP1) plays important roles in tumorigenesis and cancer metastasis. The interactions between MMP1−1607 1G>2G polymorphism and risk of gastric cancer (GC) have been reported, but results remained ambiguous. To determine the association between MMP1−1607 1G>2G polymorphism and risk of GC, we conducted a meta-analysis and identified the outcome data from all the research papers estimating the association between MMP1−1607 1G>2G polymorphism and GC risk, which was based on comprehensive searches using databases such as PubMed, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Chinese National Knowledge Infrastructure (CNKI). The fixed-effects model was used in this meta-analysis. Data were extracted, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. In this meta-analysis, six studies involving 1,377 cases and 1,543 controls were included. We identified the significant association between MMP1−1607 1G>2G polymorphism and GC risk for allele model (OR =1.05; 95% CI, 1.01−1.08), for dominant model (OR =1.11; 95% CI, 1.08−1.15), and for recessive model (OR =1.06; 95% CI, 0.98−1.14). In summary, our analysis demonstrated that MMP1−1607 1G>2G polymorphism was significantly associated with an increased risk of GC. Dove Medical Press 2015-09-10 /pmc/articles/PMC4574801/ /pubmed/26392779 http://dx.doi.org/10.2147/OTT.S83004 Text en © 2015 Peng and Xu. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Peng, Qisong Xu, Yong Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title | Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title_full | Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title_fullStr | Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title_full_unstemmed | Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title_short | Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
title_sort | association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574801/ https://www.ncbi.nlm.nih.gov/pubmed/26392779 http://dx.doi.org/10.2147/OTT.S83004 |
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