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Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity

Homozygous glucagon-GFP knock-in mice (Gcg (gfp/gfp)) lack proglucagon derived-peptides including glucagon and GLP-1, and are normoglycemic. We have previously shown that Gcg (gfp/gfp) show improved glucose tolerance with enhanced insulin secretion. Here, we studied glucose and energy metabolism in...

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Detalles Bibliográficos
Autores principales:	Takagi, Yusuke, Kinoshita, Keita, Ozaki, Nobuaki, Seino, Yusuke, Murata, Yoshiharu, Oshida, Yoshiharu, Hayashi, Yoshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574859/ https://www.ncbi.nlm.nih.gov/pubmed/26378455 http://dx.doi.org/10.1371/journal.pone.0138322

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