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TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells

The cellular protease TMPRSS2 cleaves and activates the influenza virus hemagglutinin (HA) and TMPRSS2 expression is essential for viral spread and pathogenesis in mice. Moreover, severe acute respiratory syndrome coronavirus (SARS-CoV) and other respiratory viruses are activated by TMPRSS2. However...

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Detalles Bibliográficos
Autores principales:	Zmora, Pawel, Moldenhauer, Anna-Sophie, Hofmann-Winkler, Heike, Pöhlmann, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574978/ https://www.ncbi.nlm.nih.gov/pubmed/26379044 http://dx.doi.org/10.1371/journal.pone.0138380

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