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High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains

Discovering new binding function via a combinatorial library in small protein scaffolds requires balance between appropriate mutations to introduce favorable intermolecular interactions while maintaining intramolecular integrity. Sitewise constraints exist in a non-spatial gradient from diverse to c...

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Detalles Bibliográficos
Autores principales:	Woldring, Daniel R., Holec, Patrick V., Zhou, Hong, Hackel, Benjamin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575168/ https://www.ncbi.nlm.nih.gov/pubmed/26383268 http://dx.doi.org/10.1371/journal.pone.0138956

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