Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes

The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantan...

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Detalles Bibliográficos
Autores principales: Jacovas, Vanessa Cristina, Rovaris, Diego Luiz, Peréz, Orlando, de Azevedo, Soledad, Macedo, Gabriel Souza, Sandoval, José Raul, Salazar-Granara, Alberto, Villena, Mercedes, Dugoujon, Jean-Michel, Bisso-Machado, Rafael, Petzl-Erler, Maria Luiza, Salzano, Francisco Mauro, Ashton-Prolla, Patricia, Ramallo, Virginia, Bortolini, Maria Cátira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575214/
https://www.ncbi.nlm.nih.gov/pubmed/26382048
http://dx.doi.org/10.1371/journal.pone.0137823

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